Scientific Program

3rd International Congress on Deuterium Depletion

7 May 2015, Thursday 10:30-12:00

Workshop:
¹H and ¹³C Roadmaps for Nuclear Magnetic Resonance Spectroscopy - Methods, Standards and Applications

Chairs:
Prof. Dr. Justine P. Roth (Johns Hopkins University, USA)
Dr. Csilla Ari (University of South Florida, USA)

10:30-11:00

NMR applications for Systems Biology and Metabolic Profiling: Why standardized methods are called for
Prof. Dr. Ulrich L. Günther
Professor of Biophysical Chemistry and Scientific Director, The Henry Wellcome Building for Biomolecular NMR, School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK, EU

11:00-11:30

Biochemical interpretations of ²H/¹H ratio contrast magnetic resonance spectroscopy: tissue phenotyping by mitochondrial matrix (metabolic ¹H₂O) and cytoplasmic (²H¹HO) water ratios in cells
Prof. Dr. László G. Boros
Professor of Pediatrics and Chief Scientific Advisor, SiDMAP, LLC, Department of Pediatrics, University of California Los Angeles (UCLA) School of Medicine and The Los Angeles Biomedical Research Institute (LABIOMED), Torrance, CA, USA

11:30-12:00

Magnetic Resonance Imaging - its Added Value in Clinical Diagnostic Procedures and Future Trends
Dr. András Vargha
Chair, National Quality Standards and Clinical Audits, Radiology, Budapest, Hungary, EU

7 May 2015, Thursday 14:00-17:30

Afternoon Session:
Kinetic Isotope Effects and Biological Chemistry of Deuterium Depletion (14:00-17:30)

10:00-	Registration, welcome coffee
14:00		OPENING REMARKS (To be announced)
14:10-15:00	1	Prof. Dr. Justine P. Roth Department of Chemistry, Johns Hopkins University, Baltimore, Maryland, USA ANOMALOUS DEUTERIUM KINETIC ISOTOPE EFFECTS ON FATTY ACID OXIDATION: IMPLICATIONS FOR ISOTOPE DISCRIMINATION IN BIOLOGY
15:00-15:20	2	Prof. Dr. Roman Zubarev Karolinska Institute, Stockholm, Sweden, EU ESCHERICHIA COLI GROWTH RATE MEASUREMENTS VERIFY THE ISOTOPIC RESONANCE HYPOTHESIS
15:20-15:40	3	Prof. Dr. Valentin Lobyshev Physical Faculty, M.V. Lomonosov Moscow State University, Moscow, Russian Federation SOME PHYSICO-CHEMICAL PROPERTIES OF DEUTERIUM DEPLETED WATER
15:40-16:00	Coffee break
16:00-16:20	4	Dr. Mariya Morozova Peoples’ Friendship University of Russia, Moscow, Russian Federation PHYSICO-CHEMICAL PROPERTIES OF DDW AS ITS QUALITY INDICATORS FOR PHARMACEUTICAL ANALYSIS PRACTICE
16:20-16:40	5	Prof. Dr. Stephan Dzhimak Kuban State University, Krasnodar, Russian Federation INFLUENCE OF DEUTERIUM DEPLETED WATER ON FREEZE DRIED TISSUE ISOTOPIC COMPOSITION AND MORPHOFUNCTIONAL BODY PERFORMANCE IN RATS OF DIFFERENT GENERATIONS
16:40-17:00	6	Olga Titorovich Peoples’ Friendship University of Russia, Moscow, Russian Federation INFLUENCE OF DEUTERIUM DEPLETED WATER ON BIOLOGICAL ACTIVITY/TOXICITY COMPONENTS OF PHARMACEUTICALS
17:00-17:30		OPEN DISCUSSION WITH PRESENTERS
18:00	Gala Dinner

8 May 2015, Friday 09:30-16:30

Morning Session:
Biochemical aspects and mechanism of action of deuterium depletion

9:00-9:50	7	Dr. Dominic P. D’Agostino Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, Hyperbaric Biomedical Research Laboratory, University of South Florida, Tampa, FL NON-TOXIC METABOLIC MANAGEMENT OF METASTATIC CANCER: NOVEL COMBINATION OF KETOGENIC DIET, KETONE SUPPLEMENTATION, AND HYPERBARIC OXYGEN THERAPY
9:50-10:10	8	Dr. Csilla Ari Department of Molecular Pharmacology and Physiology, Hyperbaric Biomedical Research Laboratory, Morsani College of Medicine, University of South Florida, Tampa FL, USA NEUROPROTECTIVE METABOLIC THERAPIES BY KETOGENIC ENHANCEMENT OF THE SZENTGYÖRGYI-KREBS CYCLE: STUDIES IN ANIMAL MODELS
10:10-10:30	Coffee break
10:30-10:50	9	Dr. Brandon Cline INSERM University of Strasbourg, Strasbourg, France DEUTERIUM CONTENT OF WATER AND GLUCOSE TOLERANCE: POTENTIAL ROLE FOR THE PREVALENCE OF AFFECTIVE DISTURBANCES
10:50-11:10	10	Dr. Gábor Somlyai HYD LLC for Cancer Research and Drug Development, Budapest, Hungary, EU EFFECT OF DEUTERIUM DEPLETION ON GLUCOSE TOLERANCE, SERUM HDL- AND Na+-CONCENTRATION
11:10-11:30	11	Prof. Dr. Valentin Lobyshev Physical Faculty, M.V. Lomonosov Moscow State University, Moscow, Russian Federation ISOTOPIC EFFECTS OF DEUTERIUM IN WATER ON RESPIRATION RATE, PHOSPHORYLATION AND HYDROGEN PEROXIDE GENERATION BY RAT LIVER MITOCHONDRIA
11:30-11:50	12	Prof. Dr. Marta Cascante Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Catalonia, Spain, EU BIOCHEMISTRY OF METABOLIC TRACERS FOR SYSTEMS BIOLOGY, PHENOTYPE TESTING AND DRUG RESEARCH
12:00-13:00	Lunch

Afternoon Session:
Biological and clinical applications of deuterium depletion

13:00-13:50	13	Prof. Dr. László G. Boros Department of Pediatrics, Harbor-UCLA Medical Center, UCLA School of Medicine, Los Angeles, The Los Angeles Biomedical Research Institute (LABiOMED), Torrance, California, and SIDMAP, LLC, Culver city, CA, USA GLUCONEOGENESIS AND THE PENTOSE CYCLE IMPACT DEUTERIUM DEPLETED WATER EFFICACY IN ANTICANCER THERAPEUTICS
13:50-14:10	14	Dr. Balázs Barna Plant Protection Institute, Research Centre for Agriculture, Hungarian Academy of Sciences EFFECT OF REDUCED DEUTERIUM CONCENTRATION OF WATER ON GERMINATION, SHOOT AND ROOT DEVELOPMENT, AS WELL AS ON SOD AND CAT ISOENZYME PATTERNS OF WHEAT AND SUNFLOWER
14:10-14:30	Coffee break
14:30-14:50	15	Prof. Dr. Igor Pomytkin ZAO Legkaya voda, Moscow, Russian Federation DEUTERIUM AS A RISK FACTOR FOR MENTAL DISORDERS
14:50-15:40	16	Dr. Gábor Somlyai HYD LLC for Cancer Research and Drug Development, Budapest, Hungary, EU DEUTERIUM DEPLETION RESULTS IN SEVERAL FOLD INCREASES IN THE MEDIAN SURVIVAL TIME OF CANCER PATIENTS DURING ONCOTHERAPY
15:40-16:10		DISCUSSIONS, CLOSING REMARKS - MEETING ADJOURNED